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Dosing and usage

In accordance with
its instructions for use,

Patients insert and press to administer neffy1

In studies that evaluated device administration,
100% of adult and pediatric participants
administered neffy without error2,3*

After removing neffy from packaging, patients and caregivers should4:

1

HOLD as shown. Do not test spray.4

2

INSERT nozzle into nostril until fingers touch nose. Hold straight.1,4

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Do not angle to septum or side wall of nose.1,4

3

PRESS plunger firmly. No inhalation required.1,4

A graphic depiction of the administration of neffy® (epinephrine nasal spray): INSERT the nozzle into one nostril and PRESS the plunger to release the drug
Recommended Dosage1
Patient’s WeightDosage
30 kg or greaterOne spray of neffy 2 mg
15 kg to lesss than 30 kgOne spray of neffy 1 mg

If symptoms get worse or reoccur after 5 minutes, use a new neffy nasal spray device to give a SECOND dose in the same nostril.1

*Adults and caregivers (n=50); pediatric (n=8).2,3

Preparing for administration of neffy:

  • Each single-use neffy device delivers either 1 mg or 2 mg, depending on patient weight: 1 mg for patients 15 to 30 kg and 2 mg for those ≥30 kg1
  • Patients should not prime or attempt to reuse neffy for more than one administration1
  • neffy can be administered while the patient is in any position (eg, supine, semi-supine, standing, or sitting)5

Following administration of neffy:

  • In the absence of clinical improvement or if symptoms worsen after the initial treatment, a second dose of neffy may be administered in the same nostril with a second nasal spray starting 5 minutes after the first dose1
  • If more than 2 sequential doses are required, additional doses should be administered under direct medical supervision1

Patients should be advised on when to seek emergency medical assistance for close monitoring of the anaphylactic episode and in the event further treatment is required1

Help your patients stay ready with the convenience of neffy2

Image of neffy device spraying

Intuitive Design

neffy is designed to be easy to use and carry for patients, caregivers, or anyone responsible for someone with a history of type I allergic reactions, including anaphylaxis1,2,6

Image of thermometer

Flexible Storage Conditions

Store at 68°F to 77°F
(20°C to 25°C)1
Excursions permitted up to 122°F (50°C) for a few days1
 Do not freeze. neffy freezes below 5°F (-15°C). If neffy freezes, it will not deliver epinephrine1

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Extended Shelf Life

neffy lasts longer than epinephrine needle-injectors with an expiration date up to 2.5 years after its manufacture date, depending on the dose7-9

References: 1. neffy [prescribing information]. San Diego, CA: ARS Pharmaceuticals, Inc. 2. Casale TB, Lockey R, Portnoy J, et al. Pharmacokinetics of self-administration of ARS-1 (neffy® nasal spray) 2.0 mg versus manual intramuscular (IM) epinephrine 0.3 mg by health care provider (HCP). Presented at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting; February 24, 2023; San Antonio, TX. 3. Data on file. Results for ARS neffy post-validation supplemental study for carrying case. Eurofins Human Factors MD. 2024. 4. neffy [instructions for use]. San Diego, CA: ARS Pharmaceuticals Operations, Inc. 5. Data on file. ARS Pharmaceuticals Operations, Inc. 2024. 6. Kaplan H, Rooney E, Tanimoto S, Lowenthal R. Epinephrine via needle-free device would be administered faster after symptoms: results of a patient/caregiver survey. Presented at the Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology; November 11, 2022; Louisville, KY. 7. Data on file. neffy expiration 2024. ARS Pharmaceuticals Operations, Inc. 2024. 8. ARS Pharmaceuticals Operations, Inc. ARS Pharmaceuticals announces OptumRx, Cigna Healthcare and Navitus Health Systems add neffy® (epinephrine nasal spray) to national formularies, further expanding coverage for patients [press release]. https://ir.ars-pharma.com/node/9981/pdf. February 21, 2025. Accessed March 26, 2025. 9. Shaker M, Greenhawt M. Association of fatality risk with value-based drug pricing of epinephrine autoinjectors for children with peanut allergy: a cost-effectiveness analysis. JAMA Netw Open. 2018;1(7):e184728.

IMPORTANT SAFETY INFORMATION & INDICATION

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IMPORTANT SAFETY INFORMATION

It is recommended that patients are prescribed and have immediate access to two neffy nasal sprays at all times. In the absence of clinical improvement or if symptoms worsen after initial treatment, administer a second dose of neffy in the same nostril with a new nasal spray starting 5 minutes after the first dose.

INDICATION

neffy is indicated for emergency treatment of type I allergic reactions, including anaphylaxis, in adult and pediatric patients aged 4 years and older who weigh 15 kg or greater.

neffy is for use in the nose only.

Advise patients when to seek emergency medical assistance for close monitoring of the anaphylactic episode and in the event further treatment is required.

Absorption of neffy may be affected by underlying structural or anatomical nasal conditions.

Administer with caution to patients who have heart disease; epinephrine may aggravate angina pectoris or produce ventricular arrhythmias. Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or taking cardiac glycosides, diuretics, or anti-arrhythmics.

The presence of a sulfite in neffy should not deter use.

neffy may alter nasal mucosa for up to 2 weeks after administration and increase systemic absorption of nasal products, including neffy.

Patients with certain medical conditions or who take certain medications for allergies, depression, thyroid disorders, diabetes, and hypertension, may be at greater risk for adverse reactions.

Epinephrine can temporarily exacerbate the underlying condition or increase symptoms in patients with the following: hyperthyroidism, Parkinson’s disease, diabetes, renal impairment. Epinephrine should be administered with caution in patients with these conditions, including elderly patients and pregnant women.

Most common adverse reactions are nasal discomfort, headache, rhinorrhea, dizziness, nausea, vomiting, throat irritation, nasal congestion, paresthesia, sneezing, upper respiratory tract congestion, epistaxis, rhinalgia, nasal dryness, dry throat, fatigue, and feeling jittery.

These are not all of the possible side effects of neffy. To report suspected adverse reactions, contact ARS Pharmaceuticals Operations, Inc. at 1-877-MY-NEFFY (877-696-3339) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information for neffy.