Importance of epinephrine use

In the event of an allergic reaction,

Many patients are not prepared with an epinephrine needle injector on hand^1-4

3.2 million patients filled or refilled
3.3 million patients did not fill or refill

Of the ~6.5 million patients prescribed epinephrine

50%

did not fill or refill their prescription¹*

55–60%

of patients do not consistently carry epinephrine^2-4†

40–45% do carry

Against an allergic reaction,

Many patients and caregivers don't use epinephrine promptly^2,5,6

~40%

of patients and caregivers

do not administer epinephrine at all^2‡

>50%

of parents

are afraid or somewhat afraid to administer their child’s epinephrine^5§

Patients and caregivers who hesitate to use epinephrine wait an average of over 10 minutes^6||

FOR PATIENTS WITH An allergic reaction,

A needle-free device is more likely to be carried and used sooner^6,7

Based on 2 surveys, each with 100 patients^6,7:

A white circle with a green-teal gradient background and two blue hands almost touching in the center of it

76% of patients would be more likely to carry it^6¶

A white circle with a green-teal gradient background and a blue "RX" in the center of it

47% of patients would be more likely to fill a prescription^7#

A bar chart depicting the average time (in minutes) consumers take to use their current device vs a needle-free device

Patients and caregivers said they would use it ~45% sooner^6¶

*Based on 2023 IQVIA claims data.¹

^†Based on two surveys (917 adults and parents of children and adolescents who had been prescribed an epinephrine auto-injector and 35 pediatric patients with a documented history of food allergy) and an analysis of 587 food allergic reactions resulting from ingestion.^2-4

^‡Based on a survey of 917 adults and parents of children and adolescents who had been prescribed an epinephrine auto-injector.²

^§Based on a survey of 1209 parents of children who had been prescribed an epinephrine auto-injector.⁵

^|| Based on a survey of 100 patients and 100 caregivers who used an epinephrine auto-injector within the 12 months prior to participating in the survey.⁶

^¶Based on a 20-minute, double-blind, web-based survey which included 100 caregivers and 100 qualifying patients who used an epinephrine injectable device within the 12 months prior to participating in the survey.⁶

^#Based on a survey of 100 patients who had been diagnosed with severe or potentially life-threatening allergies.⁷

References: 1. Data on file. IQVIA Claims Data. ARS Pharmaceuticals Operations, Inc. 2023. 2. Warren CM, Zaslavsky JM, Kan K, Spergel JM, Gupta RS. Epinephrine
auto-injector carriage and use practices among US children, adolescents, and adults. Ann Allergy Asthma Immunol. 2018;121(4):479-489.e2. 3. Brooks C, Coffman A, Erwin E, Mikhail I. Diagnosis and treatment of food allergic reactions in pediatric emergency settings. Ann Allergy Asthma Immunol. 2017;119(5):467-468. 4. Curtis C, Stukus D, Scherzer R. Epinephrine preparedness in pediatric patients with food allergy: an ideal time for change. Ann Allergy Asthma Immunol. 2014;112(6):560-562. 5. Chad L, Ben-Shoshan M, Asai Y, et al. A majority of parents of children with peanut allergy fear using the epinephrine auto-injector. Allergy. 2013;68(12):1605-1609. 6. Kaplan H, Rooney E, Tanimoto S, et al. Presented at the Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology; November 11, 2022; Louisville, KY. 7. Kaplan H, Rooney E, Tanimoto S, et al. Presented at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting; February 24, 2023; San Antonio, TX.